Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4404743 | 0.99 | TPSAB1 (0.40) | TPSAB1KCNH2CYP2C9CYP2C19MEN1 | |
| SCHEMBL1380988 | 0.90 | TRPC6 (0.41) | TPSAB1KCNH2CYP2C9CYP2C19MEN1 | |
| SCHEMBL1381851 | 0.90 | TPSAB1 (0.51) | TPSAB1KCNH2CYP2C9CYP2C19MEN1 | |
| Hydrochloric Acid SCHEMBL4401941 | 0.89 | TRPC6 (0.41) | TPSAB1KCNH2CYP2C9CYP2C19MEN1 | |
| Hydrochloric Acid SCHEMBL4403389 | 0.89 | TPSAB1 (0.50) | TPSAB1KCNH2CYP2C9CYP2C19MEN1 | |
| Hydrochloric Acid SCHEMBL6486065 | 0.89 | TPSAB1 (0.50) | TPSAB1KCNH2CYP2C9CYP2C19MEN1 | |
| SCHEMBL7021172 | 0.85 | TPSAB1 (0.53) | TPSAB1 | |
| Hydrochloric Acid SCHEMBL6321910 | 0.84 | MEN1 (0.41) | KCNH2CYP2C9MEN1KMT2ATRPC6 | |
| Hydrochloric Acid SCHEMBL4402047 | 0.84 | TPSAB1 (0.52) | TPSAB1 | |
| Hydrochloric Acid SCHEMBL27528148 | 0.84 | NAMPT (0.41) | TPSAB1KCNH2CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |