SCHEMBL7019519

SCHEMBL7019519

O=CCc1c(OCc2ccccc2)cccc1OCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.55
L3MBTL1 Q9Y468 2/20 0.55
MAPK1 P28482 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
CCNB2 O95067 1/20 0.54
CDK1 P06493 1/20 0.54
CDK4 P11802 1/20 0.54
CCNB1 P14635 1/20 0.54
CCND1 P24385 1/20 0.54
CCNB3 Q8WWL7 1/20 0.54
ALPG P10696 1/20 0.47
PTK2B Q14289 1/20 0.47
HTR1A P08908 6/20 0.47
DRD2 P14416 1/20 0.47
SGMS2 Q8NHU3 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MAOB P27338 2/20 0.46
MAOA P21397 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4980596 0.92 HTR1A (0.53) MAPTL3MBTL1MAPK1TDP1CCNB2
SCHEMBL16151391 0.89 HTR1A (0.51) MAPTL3MBTL1MAPK1TDP1CCNB2
SCHEMBL7019839 0.87 CCNB2 (0.43) MAPTL3MBTL1MAPK1TDP1CCNB2
SCHEMBL11046067 0.84 HTR1A (0.52) MAPTL3MBTL1MAPK1TDP1CCNB2
SCHEMBL872421 0.82 HTR1A (0.61) MAPTL3MBTL1MAPK1TDP1CCNB2
SCHEMBL2489060 0.80 HTR1A (0.52) TDP1HTR1ANPC1RAB9ASMN1; SMN2
SCHEMBL20767525 0.78 CCNB2 (0.58) MAPTL3MBTL1MAPK1TDP1CCNB2
SCHEMBL3923636 0.78 MAPT (0.66) MAPTL3MBTL1MAPK1TDP1CCNB2
SCHEMBL8584676 0.78 CCNB2 (0.57) MAPTL3MBTL1MAPK1TDP1CCNB2
SCHEMBL10826146 0.77 SLC2A1 (0.54) MAPTL3MBTL1CCNB2CDK1CDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1326856-A1 PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-BETA) INHIBITING ACTIVITY Bayer Aktiengesellschaft (DE) 2003-07-16 EP disclosed
WO-2002024679-A1 PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-β) INHIBITING ACTIVITY BAYER AKTIENGESELLSCHAFT (DE) 2002-03-28 WO disclosed