Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019519 | 0.84 | MAPT (0.55) | HTR1AADRA1DADRA1AADRA1BSGMS2 | |
| SCHEMBL16148965 | 0.82 | KMT2A (0.46) | KDM4ENPC1RAB9ARECQLMEN1 | |
| SCHEMBL11145780 | 0.81 | HTR1A (0.49) | HTR1AADRA1DADRA1AADRA1BSGMS2 | |
| SCHEMBL2305236 | 0.81 | NPC1 (0.68) | HTR1AADRA1DADRA1AADRA1BSGMS2 | |
| SCHEMBL30015078 | 0.81 | NPC1 (0.68) | HTR1AADRA1DADRA1AADRA1BSGMS2 | |
| Bicarbonate SCHEMBL27356776 | 0.80 | HTR1A (0.51) | HTR1AADRA1DADRA1AADRA1BSGMS2 | |
| SCHEMBL8406051 | 0.80 | SGMS2 (0.54) | HTR1AADRA1DADRA1AADRA1BSGMS2 | |
| SCHEMBL4290434 | 0.80 | POLB (0.55) | HTR1AADRA1DADRA1AADRA1BNPC1 | |
| SCHEMBL11048268 | 0.79 | ALDH1A1 (0.57) | HTR1AADRA1DADRA1AADRA1BKDM4E | |
| SCHEMBL9528862 | 0.79 | HTR1A (0.54) | HTR1AADRA1DADRA1AADRA1BSGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4454337-A | Semicarbazide intermediates for preparing 4-substituted indoles | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-12 | — | — | US | claimed |
| US-4454337-A | Semicarbazide intermediates for preparing 4-substituted indoles | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4394514-A | Processes for preparing 4-substituted indoles | SMITHKLINE BECKMAN CORPORATION (US) | 1983-07-19 | — | — | US | disclosed |