Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.55 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016344 | 0.90 | CA12 (0.56) | CA9CA12TBXAS1PKMKMT2A | |
| SCHEMBL7022854 | 0.81 | CYP1A2 (0.59) | CA9CA12KDM4EHPGDKMT2A | |
| SCHEMBL31207287 | 0.77 | CYP1A2 (0.62) | CA9CA12TBXAS1CMA1ACHE | |
| SCHEMBL9631092 | 0.76 | CA9 (0.59) | CA9CA12TBXAS1CMA1ACHE | |
| SCHEMBL17241716 | 0.76 | CA9 (0.59) | CA9CA12CMA1ACHEKDM4E | |
| SCHEMBL7023017 | 0.75 | KDM4E (0.56) | KDM4EHPGDKMT2AMPOXDH | |
| SCHEMBL11011553 | 0.75 | CA9 (0.61) | CA9CA12TBXAS1CMA1ACHE | |
| SCHEMBL17242523 | 0.74 | KDM4E (0.56) | CA9CA12ACHEKDM4EGAA | |
| SCHEMBL1261585 | 0.74 | USP2 (0.58) | CA9CA12TBXAS1CMA1ACHE | |
| SCHEMBL7019423 | 0.73 | ALDH1A1 (0.66) | KDM4EGAAHPGDKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | claimed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | claimed |
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |