Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1624628 | 0.78 | MEN1 (0.43) | PARP14MEN1KMT2AMAPK1KDM4E | |
| SCHEMBL18880697 | 0.78 | CYP1A2 (0.56) | MEN1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL1624553 | 0.75 | PDE4B (0.40) | MEN1KMT2AL3MBTL1MAPK1NPC1 | |
| SCHEMBL9726830 | 0.75 | ABCG2 (0.49) | MEN1KMT2AL3MBTL1KDM4ECYP1A2 | |
| SCHEMBL25003855 | 0.73 | IGF1R (0.46) | MEN1KMT2AL3MBTL1NPC1CYP1A2 | |
| SCHEMBL7169360 | 0.71 | NOS3 (0.43) | PARP14MEN1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL25003859 | 0.70 | MEN1 (0.42) | MEN1KMT2AL3MBTL1MAPK1KDM4E | |
| SCHEMBL3948774 | 0.70 | NR1I2 (0.44) | PARP14MEN1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL31026410 | 0.70 | KDM4E (0.47) | MEN1KMT2AKDM4ENPC1GUSB | |
| SCHEMBL8738417 | 0.68 | HPGD (0.52) | MEN1KMT2AL3MBTL1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101967146-B | Aryl or heteroaryl fused imidazole compounds as anti-inflammatory and analgesic agents | RAQUALIA PHARMA INC | 2015-04-08 | — | — | CN | disclosed |
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |