Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.49 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726900 | 0.79 | MERTK (0.51) | ABCG2ALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL18880697 | 0.79 | CYP1A2 (0.56) | ABCG2ALDH1A1KDM4EGAACYP1A2 | |
| SCHEMBL14946742 | 0.76 | CYP2C9 (0.54) | ABCG2TERTALDH1A1KDM4EGAA | |
| SCHEMBL7356335 | 0.76 | CYP1A2 (0.66) | ABCG2TERTSLC2A1ABCB1CYP1A2 | |
| SCHEMBL25003855 | 0.75 | IGF1R (0.46) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL7019929 | 0.75 | PARP14 (0.42) | ALDH1A1KDM4EGAACYP1A2CYP3A4 | |
| SCHEMBL1624553 | 0.74 | PDE4B (0.40) | MAPKAPK2LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL10839945 | 0.72 | SLC2A1 (0.66) | ABCG2TERTSLC2A1ABCB1GSK3B | |
| SCHEMBL23221555 | 0.72 | ABCG2 (0.66) | ABCG2GAASLC2A1ABCB1CYP1A2 | |
| SCHEMBL6384780 | 0.72 | CYP1A2 (0.38) | KDM4EGAACYP1A2CYP2D6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149814-A | Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds | PFIZER INC (US) | 1992-09-22 | — | — | US | disclosed |
| US-5120747-A | Antiallergens, antiinflammatory agent | PFIZER INC. (US) | 1992-06-09 | — | — | US | disclosed |
| US-5070205-A | Chemical intermediate for anticoagulants | PFIZER INC. (US) | 1991-12-03 | — | — | US | disclosed |
| EP-0310386-B1 | 4-ARYL-5-CARBAMOYL-1,4-DIHYDROPYRIDINES | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-5063237-A | Antiallergens and antiinflammatory agents | PFIZER INC. (US) | 1991-11-05 | — | — | US | disclosed |
| US-4963560-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1990-10-16 | — | — | US | disclosed |
| US-4935430-A | Platelet activating factor antagonists | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| EP-0365140-A1 | 1,4-Dihydropyridine derivatives | Pfizer Limited (GB) | 1990-04-25 | — | — | EP | disclosed |
| EP-0310386-A2 | 4-Aryl-5-carbamoyl-1,4-dihydropyridines | Pfizer Limited (GB) | 1989-04-05 | — | — | EP | disclosed |