Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020035 | 1.00 | TDP1 (0.43) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL6327561 | 0.88 | KMT2A (0.43) | TDP1IDO1MEN1KMT2ATDO2 | |
| SCHEMBL6326726 | 0.88 | KMT2A (0.43) | TDP1IDO1MEN1KMT2ATDO2 | |
| SCHEMBL6326737 | 0.88 | AGTR1 (0.50) | TDP1KDRIDO1MAPTKMT2A | |
| SCHEMBL6326735 | 0.88 | AGTR1 (0.50) | TDP1KDRIDO1MAPTKMT2A | |
| SCHEMBL6319003 | 0.88 | PIM1 (0.50) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL6320473 | 0.88 | PIM1 (0.50) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL6981480 | 0.87 | PAK4 (0.42) | MAPTKMT2ABACE1POLBGSK3B | |
| SCHEMBL6981475 | 0.87 | PAK4 (0.42) | MAPTKMT2ABACE1POLBGSK3B | |
| SCHEMBL6320785 | 0.86 | ALDH1A1 (0.49) | TDP1KDRIDO1CACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115704-B1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-06-18 | — | — | EP | disclosed |