Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | BRS3 | P32247 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017402 | 0.85 | AGTR1 (0.44) | AGTR1AGTR2PPARGALDH1A1 | |
| SCHEMBL7020510 | 0.82 | PPARA (0.44) | PTPN11AGTR1AGTR2 | |
| SCHEMBL7020436 | 0.81 | AGTR1 (0.47) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL7017865 | 0.80 | AGTR1 (0.48) | AGTR1AGTR2LTB4R2 | |
| SCHEMBL30850132 | 0.79 | SLC6A2 (0.45) | PPARG | |
| SCHEMBL7020223 | 0.77 | PTPN11 (0.43) | PTPN11AGTR1AGTR2PPARGBRS3 | |
| SCHEMBL29996536 | 0.73 | CYP11B1 (0.58) | PTPN11AGTR1AGTR2PPARGLTB4R2 | |
| SCHEMBL9090044 | 0.72 | PTPN11 (0.53) | PTPN11AGTR1AGTR2PPARGBRS3 | |
| SCHEMBL9723846 | 0.68 | ALDH1A1 (0.58) | PTPN11AGTR1PPARGBRS3ALDH1A1 | |
| SCHEMBL6422373 | 0.67 | PTPN11 (0.59) | PTPN11BRS3ALDH1A1LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574174-B1 | Angiotensin II antagonists | LILLY CO ELI (US) | 2003-08-13 | — | — | EP | disclosed |
| US-5693633-A | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
| US-5612360-A | AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS | ELI LILLY AND COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| US-5569768-A | USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY | ELI LILLY AND COMPANY (US) | 1996-10-29 | — | — | US | disclosed |
| US-5556981-A | Angiotensin II antagonist intermediates | ELI LILLY AND COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0574174-A2 | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1993-12-15 | — | — | EP | disclosed |