Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.56 |
| ▸ | TAOK1 | Q7L7X3 | 7/20 | 0.56 |
| ▸ | TAOK3 | Q9H2K8 | 6/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020281 | 1.00 | KCNH2 (0.56) | KCNH2SCN9ATAOK1TAOK3MTNR1A | |
| SCHEMBL7028131 | 0.86 | KCNH2 (0.72) | KCNH2SCN9ATAOK1TAOK3MTNR1A | |
| SCHEMBL7020770 | 0.86 | KCNH2 (0.72) | KCNH2SCN9ATAOK1TAOK3MTNR1A | |
| SCHEMBL7020765 | 0.86 | KCNH2 (0.72) | KCNH2SCN9ATAOK1TAOK3MTNR1A | |
| SCHEMBL4788553 | 0.86 | KCNH2 (0.55) | KCNH2SCN9ATAOK1TAOK3MTNR1A | |
| SCHEMBL7024601 | 0.82 | HTR2A (0.54) | KCNH2SCN9AMTNR1AMTNR1BSLC6A5 | |
| SCHEMBL7027975 | 0.82 | HTR2A (0.54) | KCNH2SCN9AMTNR1AMTNR1BSLC6A5 | |
| SCHEMBL7029768 | 0.80 | HTR2A (0.56) | TAOK3MTNR1AMTNR1BHTR2ADRD3 | |
| SCHEMBL7024708 | 0.80 | HTR2A (0.56) | TAOK3MTNR1AMTNR1BHTR2ADRD3 | |
| SCHEMBL7246706 | 0.76 | KCNH2 (0.63) | KCNH2SCN9ATAOK1TAOK3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | claimed |
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |
| EP-0888319-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | Astra Aktiebolag (SE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034883-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1997-09-25 | — | — | WO | disclosed |