Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.72 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.72 |
| ▸ | TAOK3 | Q9H2K8 | 3/20 | 0.57 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020770 | 1.00 | KCNH2 (0.72) | KCNH2SCN9ATAOK3TAOK1GAA | |
| SCHEMBL7020765 | 1.00 | KCNH2 (0.72) | KCNH2SCN9ATAOK3TAOK1GAA | |
| SCHEMBL7026264 | 0.88 | MTNR1A (0.59) | KCNH2SCN9AGAAMAPTSCN5A | |
| SCHEMBL7026262 | 0.88 | MTNR1A (0.59) | KCNH2SCN9AGAAMAPTSCN5A | |
| SCHEMBL7020283 | 0.86 | KCNH2 (0.56) | KCNH2SCN9ATAOK3TAOK1GAA | |
| SCHEMBL7020281 | 0.86 | KCNH2 (0.56) | KCNH2SCN9ATAOK3TAOK1GAA | |
| SCHEMBL7246702 | 0.86 | KCNH2 (0.63) | KCNH2SCN9ATAOK3TAOK1GAA | |
| SCHEMBL7246706 | 0.86 | KCNH2 (0.63) | KCNH2SCN9ATAOK3TAOK1GAA | |
| SCHEMBL7030362 | 0.85 | KCNH2 (0.52) | KCNH2SCN9ATAOK1MAPTSCN5A | |
| SCHEMBL7029157 | 0.85 | KCNH2 (0.52) | KCNH2SCN9ATAOK1MAPTSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |