Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.54 |
| ▸ | DRD3 | P35462 | 8/20 | 0.54 |
| ▸ | DRD2 | P14416 | 7/20 | 0.54 |
| ▸ | SLC6A5 | Q9Y345 | 5/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027975 | 1.00 | HTR2A (0.54) | HTR2ADRD3DRD2SLC6A5MTNR1A | |
| SCHEMBL6820338 | 0.85 | KCNH2 (0.55) | HTR2ADRD3DRD2SLC6A5MTNR1A | |
| SCHEMBL7025761 | 0.85 | KCNH2 (0.55) | HTR2ADRD3DRD2SLC6A5MTNR1A | |
| SCHEMBL6820334 | 0.85 | KCNH2 (0.55) | HTR2ADRD3DRD2SLC6A5MTNR1A | |
| SCHEMBL7029768 | 0.83 | HTR2A (0.56) | HTR2ADRD3DRD2MTNR1AMTNR1B | |
| SCHEMBL7024708 | 0.83 | HTR2A (0.56) | HTR2ADRD3DRD2MTNR1AMTNR1B | |
| SCHEMBL7020281 | 0.82 | KCNH2 (0.56) | HTR2ADRD3SLC6A5MTNR1AMTNR1B | |
| SCHEMBL7020283 | 0.82 | KCNH2 (0.56) | HTR2ADRD3SLC6A5MTNR1AMTNR1B | |
| SCHEMBL4788895 | 0.77 | KCNH2 (0.49) | DRD2SLC6A5MTNR1AMTNR1BMEN1 | |
| SCHEMBL7031232 | 0.77 | MEN1 (0.55) | DRD2MTNR1AMTNR1BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | claimed |
| US-20030130287-A1 | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists | MERCK PATENT GMBH (DE) | 2003-07-10 | — | — | US | disclosed |
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130287-A1 | Piperidine and piperazine derivatives which function as 5-ht2a receptor antagonists | HTR2A, HTR1A, HTR5A | HTR2A 1/4885DRD3 168/4885DRD2 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.