Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | KIF11 | P52732 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.46 |
| ▸ | MLYCD | O95822 | 2/20 | 0.44 |
| ▸ | POLQ | O75417 | 1/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14438022 | 0.94 | SMN1; SMN2 (0.71) | SMN1; SMN2KIF11MAPTRXRANR1H2 | |
| SCHEMBL19267924 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2KIF11MAPTRXRANR1H2 | |
| SCHEMBL5431864 | 0.84 | KIF11 (0.57) | SMN1; SMN2KIF11GPBAR1MLYCDPOLQ | |
| SCHEMBL2094859 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2KIF11NR1H2NR1H3GPBAR1 | |
| SCHEMBL2094862 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2KIF11NR1H2NR1H3MLYCD | |
| SCHEMBL14341655 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTSRD5A1ALDH1A1RAB9A | |
| SCHEMBL7682737 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2KIF11NR1H2NR1H3GPBAR1 | |
| SCHEMBL28250894 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2KIF11MAPTNR1H2NR1H3 | |
| SCHEMBL4402773 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPTSRD5A1ALDH1A1RAB9A | |
| SCHEMBL1177869 | 0.77 | ALDH1A1 (0.53) | SMN1; SMN2MAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337517-A1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-27 | — | — | EP | claimed |
| WO-2002030911-A1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-04-18 | — | — | WO | claimed |