Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RHEB | Q15382 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CASP6 | P55212 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.37 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.37 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441602 | 0.80 | GAA (0.53) | RAB9AMEN1KMT2ANPC1RHEB | |
| SCHEMBL30860105 | 0.80 | GAA (0.53) | RAB9AMEN1KMT2ANPC1RHEB | |
| Benzimidazole SCHEMBL28467044 | 0.75 | SMN1; SMN2 (0.45) | RAB9ANPC1MAPTHTTGAA | |
| Benzimidazole SCHEMBL29408372 | 0.73 | — | — | |
| Benzimidazole SCHEMBL29358377 | 0.73 | — | — | |
| Benzimidazole SCHEMBL461969 | 0.73 | SMN1; SMN2 (0.50) | RAB9ANPC1MAPTHTTGAA | |
| Benzimidazole SCHEMBL10931770 | 0.73 | SMN1; SMN2 (0.50) | RAB9ANPC1MAPTHTTGAA | |
| Benzimidazole SCHEMBL6009 | 0.73 | — | — | |
| Anthracene SCHEMBL175144 | 0.71 | KDM4E (0.47) | RAB9ANPC1MAPTHTTGAA | |
| Naphthalene SCHEMBL15819597 | 0.71 | KDM4E (0.46) | RAB9ANPC1MAPTHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272473-A1 | PROCESS FOR PREPARING SUBSTITUTED BENZIMIDAZOLE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001077083-A1 | PROCESS FOR PREPARING SUBSTITUTED BENZIMIDAZOLE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2001-10-18 | — | — | WO | disclosed |
| EP-0994890-A2 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998056761-A2 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-12-17 | — | — | WO | disclosed |