SCHEMBL7020719

SCHEMBL7020719

CCc1nnc(SCCC=C(F)F)o1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.35
TSHR P16473 3/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
POLB P06746 1/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34
KMT2A Q03164 1/20 0.34
KDM4E B2RXH2 1/20 0.31
HTT P42858 1/20 0.31
CYP2C19 P33261 2/20 0.30
CYP3A4 P08684 1/20 0.30
PTGS1 P23219 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7020783 0.88 KMT2A (0.40) MAPTTSHRSMN1; SMN2MEN1LMNA
SCHEMBL7020851 0.87 KMT2A (0.45) MAPTTSHRSMN1; SMN2POLBMEN1
SCHEMBL7021946 0.85 KMT2A (0.46) MAPTTSHRSMN1; SMN2POLBMEN1
SCHEMBL7024589 0.84 MAPT (0.33) MAPTTSHRMEN1LMNAKMT2A
SCHEMBL7023618 0.81 PKM (0.42) TSHRSMN1; SMN2POLBNPC1RAB9A
SCHEMBL7019493 0.77 PKM (0.38) MAPTTSHRSMN1; SMN2MEN1LMNA
SCHEMBL7023990 0.76 SMN1; SMN2 (0.46) MAPTTSHRSMN1; SMN2POLBMEN1
SCHEMBL7023366 0.73 PKM (0.32) MAPTPOLBMEN1KMT2AKDM4E
SCHEMBL7015472 0.73 KMT2A (0.41) MAPTTSHRSMN1; SMN2MEN1KMT2A
SCHEMBL7025544 0.71 NPSR1 (0.56) MAPTSMN1; SMN2MEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749433-B1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY SYNGENTA LTD (GB) 2003-05-07 EP disclosed
US-5952359-A NEMATICIDES, INSECTICIDES AND MITICIDES; 1,1-DIFLUORO-3-(THIAZOLYL OR ISOTHIAZOYL-THIO (OR SULFINYL OR SULFONYL)-PROP-1-ENE DERIVATIVES ZENECA LIMITED (GB) 1999-09-14 US disclosed
US-5912243-A NOVEL COMPOUNDS FOR CONTROLLING NEMATODES, INSECT OR ACARID PESTS ZENECA LIMITED (GB) 1999-06-15 US disclosed
US-5705516-A NEMATOCIDES, INSECTICIDES, ACARICIDES ZENECA LIMITED (GB) 1998-01-06 US disclosed
CN-1143958-A (4,4-difluorobut-3-enylthio-)-substituted heterocyclic or carbocyclic ring compounds ZENECA LTD (GB) 1997-02-26 CN disclosed
EP-0749433-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1996-12-27 EP disclosed
WO-1995024403-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1995-09-14 WO disclosed