SCHEMBL7025544

SCHEMBL7025544

FC(F)=CCCSc1nnc(-c2ccccc2)o1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.56
SMN1; SMN2 Q16637 6/20 0.56
EGFR P00533 1/20 0.55
NPC1 O15118 5/20 0.54
RAB9A P51151 5/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2C19 P33261 1/20 0.54
HPGD P15428 3/20 0.52
GSK3B P49841 2/20 0.52
MAPK1 P28482 1/20 0.52
CASP3 P42574 1/20 0.52
SENP8 Q96LD8 1/20 0.52
SENP7 Q9BQF6 1/20 0.52
SENP6 Q9GZR1 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
ALDH1A1 P00352 2/20 0.51
MAPT P10636 2/20 0.51
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51
ALOX15 P16050 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7025420 0.88 GSK3B (0.58) SMN1; SMN2NPC1RAB9ACYP1A2CYP2C19
SCHEMBL7020889 0.83 NPC1 (0.62) NPSR1SMN1; SMN2NPC1RAB9AHPGD
SCHEMBL7019603 0.83 POLB (0.57) NPSR1SMN1; SMN2EGFRNPC1RAB9A
SCHEMBL7023101 0.82 NPC1 (0.57) NPSR1SMN1; SMN2EGFRNPC1RAB9A
SCHEMBL7023336 0.81 MAPT (0.62) SMN1; SMN2NPC1RAB9AALDH1A1MAPT
SCHEMBL7028750 0.80 RAB9A (0.55) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL7018673 0.79 HSD17B10 (0.60) NPSR1SMN1; SMN2NPC1RAB9AHPGD
SCHEMBL7019909 0.79 EGFR (0.60) SMN1; SMN2EGFRNPC1RAB9AHPGD
SCHEMBL7016850 0.77 NOTUM (0.43) NPSR1SMN1; SMN2NPC1RAB9ACYP1A2
SCHEMBL9633136 0.77 NPSR1 (0.55) NPSR1SMN1; SMN2EGFRNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749433-B1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY SYNGENTA LTD (GB) 2003-05-07 EP disclosed
US-5952359-A NEMATICIDES, INSECTICIDES AND MITICIDES; 1,1-DIFLUORO-3-(THIAZOLYL OR ISOTHIAZOYL-THIO (OR SULFINYL OR SULFONYL)-PROP-1-ENE DERIVATIVES ZENECA LIMITED (GB) 1999-09-14 US disclosed
US-5912243-A NOVEL COMPOUNDS FOR CONTROLLING NEMATODES, INSECT OR ACARID PESTS ZENECA LIMITED (GB) 1999-06-15 US disclosed
US-5705516-A NEMATOCIDES, INSECTICIDES, ACARICIDES ZENECA LIMITED (GB) 1998-01-06 US disclosed
EP-0749433-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1996-12-27 EP disclosed
WO-1995024403-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1995-09-14 WO disclosed