Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026832 | 0.84 | HDAC1 (0.52) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL7021054 | 0.82 | HDAC1 (0.58) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL9016051 | 0.80 | CA12 (0.66) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL29000742 | 0.77 | CA12 (0.56) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL9322511 | 0.77 | CA12 (0.56) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL1413232 | 0.77 | CA12 (0.70) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL8940040 | 0.76 | CA12 (0.73) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL27866680 | 0.73 | CA12 (0.59) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL29602255 | 0.73 | ALDH1A1 (0.59) | CA12CA9ALDH1A1KDM4EMAPT | |
| SCHEMBL10671594 | 0.73 | CA12 (0.59) | CA12CA9ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865339-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2003-01-22 | — | — | EP | disclosed |
| US-6103739-A | BONE RESORPTION; ANTIINFLAMMATORY AGENTS, SKIN DISORDERS; ANTITUMOR-CARCINOGENIC AND METASTASES AGENTS; ANGIOGENESIS INHIBITORS; ANTIARRITHIC AGENTS; RHEUMATOID DISEASES; OSTEOARTHRITIS, PERIODONTITIS, GINGIVITIS AND CORNEAL ULCERS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-08-15 | — | — | US | disclosed |
| EP-0865339-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997003783-A9 | METALLOPROTEINASE INHIBITORS | — | 1997-04-03 | — | — | WO | disclosed |
| WO-1997003783-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |