Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.95 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.95 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.95 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.86 |
| ▸ | MEN1 | O00255 | 2/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.86 |
| ▸ | TP53 | P04637 | 1/20 | 0.86 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.86 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.86 |
| ▸ | FLT3 | P36888 | 2/20 | 0.80 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.80 |
| ▸ | AURKA | O14965 | 1/20 | 0.80 |
| ▸ | KDR | P35968 | 1/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34468184 | 0.98 | CYP1B1 (1.00) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 | |
| SCHEMBL31238120 | 0.98 | CYP1B1 (1.00) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 | |
| SCHEMBL3131502 | 0.98 | CYP1B1 (1.00) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 | |
| Sinensetin SCHEMBL29700880 | 0.93 | ABCB1 (1.00) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 | |
| Sinensetin SCHEMBL621101 | 0.93 | ABCB1 (1.00) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 | |
| Sinensetin SCHEMBL29549544 | 0.93 | ABCB1 (1.00) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 | |
| Eupatilin SCHEMBL1033509 | 0.89 | HDAC6 (1.00) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 | |
| Cirsileneol SCHEMBL2045672 | 0.89 | HSD17B2 (0.86) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 | |
| Eupatorin SCHEMBL29386042 | 0.89 | CYP1A1 (1.00) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 | |
| Eupatorin SCHEMBL30334912 | 0.89 | CYP1A1 (1.00) | CYP1B1CYP1A1CYP1A2OPRD1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9610276-B2 | Compositions and methods for glycemic control of subjects with impaired fasting glucose | KGK SYNERGIZE, INC. (CA) | 2017-04-04 | — | — | US | disclosed |
| EP-3010499-A1 | COMPOSITIONS COMPRISING AT LEAST ONE POLYMETHOXYFLAVONE, FLAVONOID, LIMINOID, AND/OR TOCOTRIENOL USEFUL IN COMBINATION THERAPIES FOR TREATING DIABETES | KGK Synergize, Inc. (CA) | 2016-04-27 | — | — | EP | disclosed |
| US-20150328184-A1 | COMPOSITIONS AND METHODS FOR GLYCEMIC CONTROL OF SUBJECTS WITH IMPAIRED FASTING GLUCOSE | 1242753 Ontario Inc. (CA) | 2015-11-19 | — | — | US | disclosed |
| US-9132117-B2 | Compositions and methods for glycemic control of subjects with impaired fasting glucose | KGK SYNERGIZE, INC (CA) | 2015-09-15 | — | — | US | disclosed |
| WO-2014203059-A1 | COMPOSITIONS COMPRISING AT LEAST ONE POLYMETHOXYFLAVONE, FLAVONOID, LIMINOID, AND/OR TOCOTRIENOL USEFUL IN COMBINATION THERAPIES FOR TREATING DIABETES | KGK SYNERGIZE, INC. (CA) | 2014-12-24 | — | — | WO | disclosed |
| US-20140371303-A1 | COMPOSITIONS AND METHODS FOR GLYCEMIC CONTROL OF SUBJECTS WITH IMPAIRED FASTING GLUCOSE | 1242753 Ontario Inc. (CA) | 2014-12-18 | — | — | US | disclosed |
| EP-1278417-A1 | COMPOSITIONS AND METHODS OF TREATING, REDUCING, AND PREVENTING CARDIOVASCULAR DISEASES AND DISORDERS WITH POLYMETHOXYFLAVONES | KGK Synergie (CA) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001070029-A1 | COMPOSITIONS AND METHODS OF TREATING, REDUCING, AND PREVENTING CARDIOVASCULAR DISEASES AND DISORDERS WITH POLYMETHOXYFLAVONES | KGK SYNERGIE (CA) | 2001-09-27 | — | — | WO | disclosed |