Sinensetin

Sinensetin

SCHEMBL621101

COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)cc3o2)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCB1 P08183 3/20 1.00
▸ MEN1 O00255 3/20 1.00
▸ KMT2A Q03164 3/20 1.00
▸ ABCG2 Q9UNQ0 3/20 1.00
▸ TP53 P04637 1/20 1.00
▸ MDM2 Q00987 1/20 1.00
▸ CYP1B1 Q16678 4/20 0.81
▸ CYP1A1 P04798 3/20 0.81
▸ CYP1A2 P05177 1/20 0.81
▸ OPRD1 P41143 1/20 0.81
▸ ALDH1A1 P00352 3/20 0.76
▸ KDM4E B2RXH2 3/20 0.71
▸ MAPT P10636 3/20 0.71
▸ HPGD P15428 2/20 0.71
▸ CYP3A4 P08684 1/20 0.71
▸ MAPK1 P28482 1/20 0.71
▸ HSD17B10 Q99714 1/20 0.71
▸ HDAC6 Q9UBN7 1/20 0.71
▸ FLT3 P36888 2/20 0.67
▸ AURKA O14965 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sinensetin SCHEMBL29700880 1.00 ABCB1 (1.00) ABCB1MEN1KMT2AABCG2TP53
Sinensetin SCHEMBL29549544 1.00 ABCB1 (1.00) ABCB1MEN1KMT2AABCG2TP53
Sinensetin SCHEMBL7020909 0.93 CYP1B1 (0.95) ABCB1MEN1KMT2AABCG2TP53
SCHEMBL8069155 0.90 ABCB1 (0.82) ABCB1MEN1KMT2AABCG2TP53
SCHEMBL31238120 0.90 CYP1B1 (1.00) ABCB1MEN1KMT2AABCG2TP53
SCHEMBL34468184 0.90 CYP1B1 (1.00) ABCB1MEN1KMT2AABCG2TP53
SCHEMBL3131502 0.90 CYP1B1 (1.00) ABCB1MEN1KMT2AABCG2TP53
SCHEMBL7606758 0.90 HDAC6 (0.84) ABCB1MEN1KMT2AABCG2TP53
SCHEMBL30375958 0.90 HDAC6 (0.84) ABCB1MEN1KMT2AABCG2TP53
SCHEMBL1765114 0.88 ABCB1 (1.00) ABCB1MEN1KMT2AABCG2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4698662-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2026-02-25 — — EP claimed
WO-2025215165-A1 LIQUID ANTIMICROBIAL COMPOSITION MINASOLVE SAS (FR) 2025-10-16 — — WO claimed
EP-4609911-A2 COMPOUNDS EFFECTIVE IN TREATING HEPATOTOXICITY AND FATTY LIVER DISEASES AND USES THEREOF Sinew Pharma Inc. (TW) 2025-09-03 — — EP claimed
EP-2603098-B1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED (US) 2025-08-06 — — EP claimed
US-20250145581-A1 PURIFICATION PROCESS FOR POLYMETHOXYLATED FLAVONOIDS AND COMPOSITIONS OBTAINED THEREFROM FIRMENICH SA (CH) 2025-05-08 — — US claimed
WO-2024220449-A9 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2025-04-03 — — WO claimed
US-20250051551-A1 IMPROVED POLYMER COMPOSITES WARNER BABCOCK INSTITUTE FOR GREEN CHEMISTRY, LLC (US) 2025-02-13 — — US claimed
US-20250032446-A1 METHODS AND COMPOSITIONS FOR THE BIOSYNTHESIS AND USE OF DEMETHYLATED POLYMETHOXY FLAVONES RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2025-01-30 — — US claimed
US-20250011393-A1 FLAVONOID-COLLAGEN CROSSLINKED ANTIOXIDANT HYDROGEL NORTH CAROLINA STATE UNIVERSITY 2025-01-09 — — US claimed
US-20240397987-A1 COMPOSITION DERIVED FROM CITRUS FRUIT AND BEVERAGE CONTAINING THE SAME SUNTORY HOLDINGS LIMITED (JP) 2024-12-05 — — US claimed
US-20020006953-A1 MODIFICATION OF CHOLESTEROL CONCENTRATIONS WITH CITUS PHYTOCHEMICALS TROPICANA PRODUCTS, INC. 2002-01-17 — — US claimed
EP-1143810-A1 A METHOD FOR SELECTIVELY OBTAINING ANTIOXIDANT RICH EXTRACTS FROM CITRUS FRUITS ADUMIM CHEMICALS LTD. (IL) 2001-10-17 — — EP claimed
WO-2001070029-A1 COMPOSITIONS AND METHODS OF TREATING, REDUCING, AND PREVENTING CARDIOVASCULAR DISEASES AND DISORDERS WITH POLYMETHOXYFLAVONES KGK SYNERGIE (CA) 2001-09-27 — — WO claimed
WO-2001032160-A2 MODIFICATION OF CHOLESTEROL CONCENTRATIONS WITH CITRUS PHYTOCHEMICALS TROPICANA PRODUCTS, INC. (US) 2001-05-10 — — WO claimed
US-6184246-B1 Inhibition of cytokine production by polymethoxylated flavones THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE 2001-02-06 — — US claimed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 — — WO claimed
WO-2000032062-A1 A METHOD FOR SELECTIVELY OBTAINING ANTIOXIDANT RICH EXTRACTS FROM CITRUS FRUITS ADUMIM CHEMICALS LTD. (IL) 2000-06-08 — — WO claimed
EP-0605261-B1 Use of a flavone derivative as taste modifier and a method of modifying taste SAN EI GEN FFI INC (JP) 1999-09-15 — — EP claimed
US-5580545-A ADDING FLAVONE DERIVATIVES TO FOODS, BEVERAGES OR TOILETRIES TO ENHANCE OR REDUCE FLAVORS SAN-EI GEN F.F.I., INC. (JP) 1996-12-03 — — US claimed
EP-0605261-A2 A taste modifier and a method of modifying taste SAN-EI GEN F.F.I., INC. (JP) 1994-07-06 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250032446-A1 METHODS AND COMPOSITIONS FOR THE BIOSYNTHESIS AND USE OF DEMETHYLATED POLYMETHOXY FLAVONES CYP51A1, CYP46A1, ERG28 ABCB1 2853/4885MEN1 3893/4885KMT2A 461/4885
US-20250145581-A1 PURIFICATION PROCESS FOR POLYMETHOXYLATED FLAVONOIDS AND COMPOSITIONS OBTAINED THEREFROM TAS2R40, TAS2R60, TAS2R45 ABCB1 4489/4885MEN1 604/4885KMT2A 4411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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