Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 13/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.56 |
| ▸ | PDE4A | P27815 | 11/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7025705 | 0.99 | ADORA2B (0.55) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL9350679 | 0.97 | PDE4A (0.54) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL7018925 | 0.97 | ADORA2B (0.56) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL7029046 | 0.94 | PDE4A (0.59) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL9354344 | 0.84 | ADORA2B (0.47) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL19210142 | 0.82 | PDE4A (0.68) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL7603838 | 0.79 | PDE4A (0.55) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL25306092 | 0.78 | PDE4A (0.66) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10978398 | 0.78 | PDE4A (0.59) | ADORA2BADORA2APDE4APDE4BPDE4C | |
| SCHEMBL6270961 | 0.77 | CDK2 (0.48) | ADORA2BADORA2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369744-B1 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-09-21 | — | — | EP | claimed |
| US-5321029-A | Vascular and skin disorders; bronchodilator | BEECHAM-WUELFING GMBH & CO.K.G. (DE) | 1994-06-14 | — | — | US | claimed |
| EP-0369744-A2 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1990-05-23 | — | — | EP | claimed |
| US-6531600-B1 | 8-substituted xanthines have a protective effect against the consequences of cerebral metabolic inhibition; cerebral vascular and neuronal degenerative disorders; 6-aminouracil intermediate is claimed | BEECHAM GROUP P.L.C. (GB) | 2003-03-11 | — | — | US | disclosed |
| EP-0389282-B1 | Xanthinederivatives, process for their preparation and their pharmaceutical use | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 2002-02-20 | — | — | EP | disclosed |
| EP-1120417-A2 | Xanthine derivatives for the treatment of cerebrovascular disorders | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 2001-08-01 | — | — | EP | disclosed |
| US-6180791-B1 | REDUCING NITRO GROUPS TO FORM AMINO GROUPS | BEECHAM GROUP P.L.C. (GB) | 2001-01-30 | — | — | US | disclosed |
| US-5981535-A | FOR TREATMENT OF ALLERGIC DISORDERS ASSOCIATED WITH ATOPY, BRONCHODILATION TO TREAT DISORDERS OF THE RESPIRATORY TRACT IN A MAMMAL | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-09 | — | — | US | disclosed |
| US-5734051-A | TREATMENT OF CEREBROVASCULAR DISORDERS AND-OR DISORDERS ASSOCIATED WITH CEREBRAL SENILITY | BEECHAM GROUP (GB) | 1998-03-31 | — | — | US | disclosed |
| EP-0369744-B1 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-09-21 | — | — | EP | disclosed |
| US-5321029-A | Vascular and skin disorders; bronchodilator | BEECHAM-WUELFING GMBH & CO.K.G. (DE) | 1994-06-14 | — | — | US | disclosed |
| EP-0389282-A2 | Xanthinederivatives, process for their preparation and their pharmaceutical use | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1990-09-26 | — | — | EP | disclosed |
| EP-0369744-A2 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |