Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.54 |
| ▸ | PDE5A | O76074 | 2/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 12/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7025705 | 0.99 | ADORA2B (0.55) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7021175 | 0.97 | ADORA2B (0.56) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7018925 | 0.94 | ADORA2B (0.56) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7029046 | 0.94 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9354344 | 0.84 | ADORA2B (0.47) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL19210142 | 0.82 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7603838 | 0.79 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL10978398 | 0.78 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL25306092 | 0.78 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL15923707 | 0.77 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369744-B1 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-09-21 | — | — | EP | disclosed |
| US-5321029-A | Vascular and skin disorders; bronchodilator | BEECHAM-WUELFING GMBH & CO.K.G. (DE) | 1994-06-14 | — | — | US | disclosed |
| EP-0369744-A2 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |