Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 8/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839703 | 1.00 | HRH3 (0.54) | HRH3DRD3DRD2NOTUMUSP30 | |
| SCHEMBL6839707 | 1.00 | HRH3 (0.54) | HRH3DRD3DRD2NOTUMUSP30 | |
| SCHEMBL6839704 | 1.00 | HRH3 (0.54) | HRH3DRD3DRD2NOTUMUSP30 | |
| SCHEMBL6842238 | 0.84 | SLC6A2 (0.51) | HRH3DRD3DRD2KMT2ATSHR | |
| SCHEMBL7106442 | 0.84 | HRH3 (0.57) | HRH3DRD3DRD2NOTUMABCC9 | |
| SCHEMBL6170154 | 0.84 | HRH3 (0.57) | HRH3DRD3DRD2NOTUMABCC9 | |
| SCHEMBL6161764 | 0.84 | HRH3 (0.57) | HRH3DRD3DRD2NOTUMABCC9 | |
| SCHEMBL1815016 | 0.79 | DRD2 (0.49) | HRH3DRD3DRD2NOTUMABCC9 | |
| SCHEMBL1815014 | 0.79 | DRD2 (0.49) | HRH3DRD3DRD2NOTUMABCC9 | |
| SCHEMBL1815012 | 0.79 | DRD2 (0.49) | HRH3DRD3DRD2NOTUMABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368341-A1 | PHENYL DERIVATIVES 3 | MERCK PATENT GmbH (DE) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002074765-A1 | PHENYL DERIVATIVES 3 | MERCK PATENT GMBH (DE) | 2002-09-26 | — | — | WO | disclosed |