Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL808427 | 0.84 | TSHR (0.42) | TSHRUSP2HTTCYP3A4DNM1 | |
| SCHEMBL7712111 | 0.82 | TSHR (0.37) | TSHRUSP2HTTCYP3A4DNM1 | |
| SCHEMBL16275184 | 0.77 | DNM1 (0.48) | LPAR1LPAR3USP2HTTDNM1 | |
| SCHEMBL7005303 | 0.76 | TDP1 (0.32) | TSHRTDP1 | |
| SCHEMBL11256054 | 0.76 | ATM (0.31) | TSHRALDH1A1 | |
| SCHEMBL18270714 | 0.75 | DNM1 (0.52) | LPAR1LPAR3USP2HTTDNM1 | |
| SCHEMBL8866099 | 0.73 | — | — | |
| SCHEMBL1462928 | 0.72 | USP2 (0.38) | TSHRLPAR1LPAR3USP2HTT | |
| SCHEMBL17832934 | 0.71 | USP2 (0.50) | LPAR1LPAR3USP2HTTLPAR5 | |
| SCHEMBL11493102 | 0.71 | TSHR (0.37) | TSHRLPAR1LPAR3USP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358154-A2 | PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2001028996-A2 | PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES | ABBOTT LABORATORIES (US) | 2001-04-26 | — | — | WO | disclosed |