Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 4/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7261235 | 0.79 | LTA4H (0.46) | HRH4NOTUMCA1CA2CA9 | |
| SCHEMBL10827533 | 0.78 | ADORA2A (0.52) | XDHCA1CA2CA9 | |
| SCHEMBL5089384 | 0.75 | TNKS (0.48) | PGRMYCNOTUMMAOBMAOA | |
| SCHEMBL29045675 | 0.73 | LTA4H (0.51) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL13492147 | 0.70 | ABCG2 (0.57) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL20427542 | 0.69 | ADORA1 (0.69) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL13288408 | 0.68 | HSP90AA1 (0.62) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL31298771 | 0.68 | CFTR (0.45) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL19862189 | 0.67 | GAA (0.56) | HRH4HRH3HTR1AADRA2AADRA2C | |
| SCHEMBL19868516 | 0.67 | MEN1 (0.55) | HRH4HRH3HTR1AADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |