Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.34 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.33 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.33 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014611 | 0.86 | MMP1 (0.51) | MMP1FPR2PROKR1TDO2LIPE | |
| SCHEMBL7021130 | 0.79 | MMP1 (0.52) | MMP1FPR2PROKR1TDO2LIPE | |
| SCHEMBL7018357 | 0.78 | MMP1 (0.49) | MMP1FPR2PROKR1TDO2LIPE | |
| SCHEMBL7011537 | 0.77 | MMP1 (0.52) | MMP1FPR2PROKR1TDO2LIPE | |
| SCHEMBL7018853 | 0.77 | MMP1 (0.56) | MMP1FPR2PROKR1TDO2LIPE | |
| SCHEMBL7018466 | 0.75 | MMP1 (0.54) | MMP1FPR2PROKR1TDO2LIPE | |
| SCHEMBL940600 | 0.75 | MMP1 (0.57) | MMP1FPR2PROKR1TDO2LIPE | |
| SCHEMBL6021557 | 0.73 | MMP1 (0.52) | MMP1FPR2PROKR1TDO2LIPE | |
| SCHEMBL7023218 | 0.72 | MMP1 (0.53) | MMP1FPR2PROKR1TDO2LIPE | |
| SCHEMBL7023309 | 0.72 | MMP1 (0.57) | MMP1FPR2PROKR1TDO2LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| EP-1370556-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074767-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |