SCHEMBL70226

SCHEMBL70226

N#Cc1nc(C#N)c(Cl)c(Cl)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.46
GAA P10253 2/20 0.46
ALDH1A1 P00352 5/20 0.43
CYP3A4 P08684 2/20 0.43
HPGD P15428 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
TP53 P04637 1/20 0.43
MAPT P10636 1/20 0.43
MAPK1 P28482 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
ALOX15 P16050 3/20 0.33
NPC1 O15118 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
ALOX12 P18054 1/20 0.32
CYP2C19 P33261 1/20 0.32
RAB9A P51151 1/20 0.32
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6443989 0.86 KDM4E (0.57) KDM4EGAAALDH1A1CYP3A4HPGD
SCHEMBL28808893 0.86 KDM4E (0.57) KDM4EGAAALDH1A1CYP3A4HPGD
SCHEMBL29705235 0.86 KDM4E (0.57) KDM4EGAAALDH1A1CYP3A4HPGD
SCHEMBL11027970 0.82 KDM4E (0.39) KDM4EGAAALDH1A1CYP3A4HPGD
SCHEMBL18837423 0.82 MEN1 (0.41) KDM4EGAAALDH1A1CYP3A4HPGD
SCHEMBL9617370 0.77 KDM4E (0.43) KDM4EGAAALDH1A1CYP3A4HPGD
SCHEMBL2051824 0.76 KDM4E (0.48) KDM4EGAAALDH1A1CYP3A4HPGD
SCHEMBL3833954 0.75 USP7 (0.37) KDM4EGAAALDH1A1MAPTMAPK1
SCHEMBL18566398 0.75 HTT (0.40) KDM4EGAAALDH1A1CYP3A4HPGD
SCHEMBL11027559 0.75 KDM4E (0.38) KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3412 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108658816-B N-aryl amidine substituted trifluoroethyl sulfide derivatives useful as acaricides and insecticides 拜尔农作物科学股份公司 2023-05-02 CN claimed
EP-3954214-A1 MULTIPURPOSE BIOLOGICAL COMPOSITIONS Agrivalle Brasil Industria e Comércio de Produtos Agrícolas Ltda (BR) 2022-02-16 EP claimed
CN-108184905-B Compositions comprising biological control agents and fungicides 拜尔农作物科学股份公司 2021-12-28 CN claimed
CN-107996613-B Compositions comprising biological control agents and pesticides 拜尔农作物科学股份公司 2021-10-22 CN claimed
CN-109169661-B Compositions comprising biological control agents and insecticides 拜耳作物科学股份公司 2021-09-21 CN claimed
CN-107926985-B Compositions comprising biological control agents and fungicides 拜尔农作物科学股份公司 2021-02-02 CN claimed
EP-3488700-B1 COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND A FUNGICIDE BAYER CROPSCIENCE AG (DE) 2020-12-16 EP claimed
US-10834921-B2 Foam formulations and apparatus for delivery FMC CORPORATION (US) 2020-11-17 US claimed
EP-2854545-B1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2020-10-21 EP claimed
WO-2020206518-A1 MULTIPURPOSE BIOLOGICAL COMPOSITIONS AGRIVALLE BRASIL INDUSTRIA E COMÉRCIO DE PRODUTOS AGRÍCOLAS LTDA (BR) 2020-10-15 WO claimed
EP-1931200-A1 FUNGICIDE COMPOSITION COMPRISING AN ARYLAMIDINE DERIVATIVE AND TWO KNOWN FUNGICIDE COMPOUNDS Bayer CropScience AG (DE) 2008-06-18 EP claimed
WO-2008046856-A2 FUNGICIDAL COMPOSITIONS BASF SE (DE) 2008-04-24 WO claimed
EP-1898709-A1 FUNGICIDE COMPOSITION COMPRISING A PHOSPHOROUS ACID DERIVATIVE, A MANDELAMIDE TYPE COMPOUND AND A FURTHER FUNGICIDE COMPOUND Bayer CropScience S.A. (FR) 2008-03-19 EP claimed
US-20070155802-A1 Fungicide composition comprising an arylamidine derivative and known fungicide compounds BAYER CROPSCIENCE S.A. (FR) 2007-07-05 US claimed
WO-2007031507-A1 FUNGICIDE COMPOSITION COMPRISING AN ARYLAMIDINE DERIVATIVE AND TWO KNOWN FUNGICIDE COMPOUNDS BAYER CROPSCIENCE AG (DE) 2007-03-22 WO claimed
WO-2006136551-A1 FUNGICIDE COMPOSITION COMPRISING A PHOSPHOROUS ACID DERIVATIVE, A MANDELAMIDE TYPE COMPOUND AND A FURTHER FUNGICIDE COMPOUND BAYER CROPSCIENCE SA (FR) 2006-12-28 WO claimed
EP-1722629-A1 FUNGICIDE COMPOSITION COMPRISING AN ARYLAMIDINE DERIVATIVE AND KNOWN FUNGICIDE COMPOUNDS Bayer CropScience S.A. (FR) 2006-11-22 EP claimed
WO-2005089547-A1 FUNGICIDE COMPOSITION COMPRISING AN ARYLAMIDINE DERIVATIVE AND KNOWN FUNGICIDE COMPOUNDS BAYER CROPSCIENCE SA (FR) 2005-09-29 WO claimed
EP-1570736-A1 Fungicide composition comprising an arylamidine derivative and known fungicide compounds Bayer CropScience S.A. (FR) 2005-09-07 EP claimed
US-4496534-A Method for reconditioning bacteria-contaminated hydrogen sulfide removing systems UNION OIL COMPANY OF CALIFORNIA (US) 1985-01-29 US claimed