Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022760 | 1.00 | ADORA3 (0.36) | ADORA3ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL7027041 | 0.89 | ADORA3 (0.37) | ADORA3ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL7027036 | 0.89 | ADORA3 (0.37) | ADORA3ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL7016851 | 0.80 | ADORA2A (0.33) | ADORA3ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL7016847 | 0.80 | ADORA2A (0.33) | ADORA3ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL7014427 | 0.78 | MAPT (0.48) | KDM4EALDH1A1PKMHTTKMT2A | |
| SCHEMBL7014430 | 0.78 | MAPT (0.48) | KDM4EALDH1A1PKMHTTKMT2A | |
| SCHEMBL7097369 | 0.77 | USP2 (0.33) | ADORA3ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL7015194 | 0.76 | ADORA3 (0.37) | ADORA3ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL7015193 | 0.76 | ADORA3 (0.37) | ADORA3ADORA2BADORA2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |