SCHEMBL7023587

SCHEMBL7023587

C=C(C(=O)CC(C)=O)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 4/20 0.45
MAPT P10636 4/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
KDM4E B2RXH2 1/20 0.45
CYP3A4 P08684 1/20 0.45
HPGD P15428 1/20 0.45
ALOX15 P16050 1/20 0.45
MAPK1 P28482 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
CES2 O00748 3/20 0.44
PTPN1 P18031 1/20 0.44
ERCC5 P28715 1/20 0.44
FEN1 P39748 1/20 0.44
TSHR P16473 1/20 0.42
EGFR P00533 2/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9710316 0.79 CES1 (0.63) CES1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL10974421 0.79 MAOA (0.50) CES1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL14974304 0.78 ERCC5 (0.67) CES1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL28813199 0.77 CES1 (0.44) CES1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL9393583 0.77 MAPK1 (0.58) CES1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL3337020 0.76 CES2 (0.58) CES1MAPTSMN1; SMN2CYP3A4HPGD
SCHEMBL28177441 0.75 CES1 (0.43) CES1MAPTMEN1KMT2ASMN1; SMN2
Benzene SCHEMBL8209405 0.74 KMT2A (0.73) CES1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL11373627 0.74 KMT2A (0.73) CES1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL15116 0.74 KMT2A (0.73) CES1MAPTMEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1091933-B1 SUBSTITUTED BETA-DIKETONES AND THEIR USE ORION CORP (FI) 2003-11-26 EP disclosed
EP-1091933-A1 SUBSTITUTED $g(b)-DIKETONES AND THEIR USE ORION CORPORATION (FI) 2001-04-18 EP disclosed
US-6201027-B1 NONSTEROIDAL ANTIINFLAMMATORY DRUG FOR PROPHYLAXIS AND TREATMENT OF RESPIRATORY SYSTEM DISORDERS, I.E. ASTHMA, IN STEROID-RESISTANT MAMMALS ORION CORPORATION (FI) 2001-03-13 US disclosed
WO-2000001667-A1 SUBSTITUTED β-DIKETONES AND THEIR USE ORION CORPORATION (FI) 2000-01-13 WO disclosed