Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014862 | 0.85 | HPGD (0.50) | MTNR1AMTNR1BHPGDCYP1A2CYP3A4 | |
| SCHEMBL7016861 | 0.84 | HPGD (0.44) | MTNR1AMTNR1BHPGDCYP1A2CYP3A4 | |
| SCHEMBL8690384 | 0.82 | MTNR1A (0.64) | MTNR1AMTNR1BNQO2KMT2AALDH1A1 | |
| SCHEMBL3456280 | 0.80 | HPGD (0.74) | HPGDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8006826 | 0.80 | MTNR1A (0.64) | MTNR1AMTNR1BNQO2ALDH1A1 | |
| SCHEMBL8695744 | 0.79 | MTNR1A (0.64) | MTNR1AMTNR1BHPGDCYP1A2CYP3A4 | |
| SCHEMBL7100233 | 0.79 | MTNR1A (0.74) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8694576 | 0.78 | MTNR1A (0.65) | MTNR1AMTNR1BHPGDCYP1A2CYP3A4 | |
| SCHEMBL10144817 | 0.75 | CYP1A2 (1.00) | HPGDCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17785106 | 0.75 | MTNR1A (0.70) | MTNR1AMTNR1BNQO2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057826-B1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-04-16 | — | — | EP | disclosed |
| US-6310074-B1 | TREATING MELATONINERGIC DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-10-30 | — | — | US | disclosed |
| EP-1057826-A1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-12-06 | — | — | EP | disclosed |