Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7025027 | 0.89 | DRD2 (0.35) | — | |
| SCHEMBL7020149 | 0.83 | PRMT5 (0.35) | PRMT5HRH3 | |
| SCHEMBL4294146 | 0.80 | HRH3 (0.39) | HRH3 | |
| SCHEMBL4295492 | 0.77 | OPRM1 (0.32) | HRH3 | |
| SCHEMBL4294247 | 0.74 | HRH3 (0.43) | HRH3CYP3A4CYP2C9KCNH2 | |
| SCHEMBL4462917 | 0.74 | SLC6A2 (0.35) | KCNH2 | |
| SCHEMBL13660586 | 0.72 | DRD2 (0.44) | CYP3A4KCNH2 | |
| SCHEMBL13660587 | 0.72 | DRD2 (0.44) | CYP3A4KCNH2 | |
| SCHEMBL13663228 | 0.72 | DRD2 (0.44) | CYP3A4KCNH2 | |
| SCHEMBL4291006 | 0.72 | DRD2 (0.44) | CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326863-A2 | OCTAHYDRO-INDOLIZINES AND QUINOLIZINES AND HEXAHYDRO-PYRROLIZINES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002024695-A2 | OCTAHYDRO-INDOLIZINES AND QUINOLIZINES AND HEXAHYDRO-PYRROLIZINES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-28 | — | — | WO | disclosed |