Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | DRD3 | P35462 | 6/20 | 0.50 |
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830330 | 1.00 | DRD2 (0.50) | DRD2DRD3HTR2AUSP30KCNH2 | |
| SCHEMBL6820453 | 1.00 | DRD2 (0.50) | DRD2DRD3HTR2AUSP30KCNH2 | |
| SCHEMBL7028302 | 0.92 | DRD2 (0.54) | DRD2DRD3HTR2AUSP30KCNH2 | |
| SCHEMBL7029323 | 0.92 | DRD2 (0.54) | DRD2DRD3HTR2AUSP30KCNH2 | |
| SCHEMBL7029319 | 0.92 | DRD2 (0.54) | DRD2DRD3HTR2AUSP30KCNH2 | |
| SCHEMBL7021230 | 0.91 | MTNR1A (0.50) | DRD2DRD3HTR2AKCNH2SCN9A | |
| SCHEMBL7021228 | 0.91 | MTNR1A (0.50) | DRD2DRD3HTR2AKCNH2SCN9A | |
| SCHEMBL7030820 | 0.91 | DRD2 (0.54) | DRD2DRD3HTR2AUSP30KCNH2 | |
| SCHEMBL7028328 | 0.91 | DRD2 (0.54) | DRD2DRD3HTR2AUSP30KCNH2 | |
| SCHEMBL6819527 | 0.91 | DRD2 (0.51) | DRD2DRD3HTR2AUSP30KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |