Sugi Predict

Sugi Predict / Compounds / SCHEMBL7024059

SCHEMBL7024059

SCHEMBL7024059

C[Si](C)(C)C[Si](C)(C)c1ccccn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ CCR1 P32246 1/20 0.37
▸ CCR5 P51681 1/20 0.37
▸ CCR8 P51685 1/20 0.37
▸ METAP1 P53582 1/20 0.37
▸ BLM P54132 1/20 0.37
▸ HIF1A Q16665 1/20 0.37
▸ DOHH Q9BU89 1/20 0.37
▸ P4HTM Q9NXG6 1/20 0.37
▸ NPC1 O15118 4/20 0.34
▸ RAB9A P51151 4/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ ATM Q13315 1/20 0.34
▸ HDAC8 Q9BY41 1/20 0.34
▸ NOS3 P29474 1/20 0.34
▸ NOS1 P29475 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7031343 0.91 LMNA (0.40) LMNAKDM4ECYP1A2POLBCCR1
SCHEMBL7027857 0.78 LMNA (0.37) LMNAKDM4ECYP1A2POLBCCR1
SCHEMBL7035341 0.78 LMNA (0.37) LMNAKDM4ECYP1A2POLBCCR1
SCHEMBL7029611 0.77 KCNA5 (0.38) LMNAKDM4ECYP1A2POLBCCR1
SCHEMBL29767661 0.76 KDM4E (0.48) LMNAKDM4ECYP1A2POLBCCR1
SCHEMBL1299154 0.76 KDM4E (0.48) LMNAKDM4ECYP1A2POLBCCR1
SCHEMBL10356611 0.74 KDM4E (0.46) LMNAKDM4ECYP1A2POLBCCR1
SCHEMBL7032571 0.74 CYP1A2 (0.41) LMNAKDM4ECYP1A2NPC1RAB9A
SCHEMBL29742195 0.74 NR1H2 (0.37) LMNAKDM4ECYP1A2POLBCCR1
SCHEMBL2328923 0.74 NR1H2 (0.37) LMNAKDM4ECYP1A2POLBCCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030139600-A1 2-pyridylsilane, processes for producing and using the same SUMITOMO CHEMICAL CO., LTD. 2003-07-24 — — US disclosed
US-6548673-B1 Alkylation using transition metal complex catalyst; purified by acid/base extraction SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-04-15 — — US disclosed
US-6531602-B2 Desilylation of a 2-pyridylsilane to form an alcohol SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-11 — — US disclosed
US-20020165397-A1 2-Pyridylsilane, processes for producing and using the same SUMITOMO CHEMICAL CO., LTD. 2002-11-07 — — US disclosed
JP-2000256370-A 2-PYRIDYLSILANE, ITS PRODUCTION AND INTERMEDIATE, AND PRODUCTION OF ALCOHOL FROM 2-PYRIDYLSILANE SUMITOMO CHEM CO LTD 2000-09-19 — — JP disclosed
EP-1035125-A2 2-Pyridylsilane, processes for producing and using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-09-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020165397-A1 2-Pyridylsilane, processes for producing and using the same H1-0, RIOK2, H1-4 LMNA 2432/4885KDM4E 825/4885CYP1A2 363/4885
US-20030139600-A1 2-pyridylsilane, processes for producing and using the same H1-0, H1-4, H1-2 LMNA 2555/4885KDM4E 903/4885CYP1A2 390/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.