Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024074 | 1.00 | MTNR1A (0.47) | MTNR1AMTNR1BTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7023560 | 0.89 | NPC1 (0.48) | MTNR1AMTNR1BNPC1ALDH1A1RAB9A | |
| SCHEMBL7023556 | 0.89 | NPC1 (0.48) | MTNR1AMTNR1BNPC1ALDH1A1RAB9A | |
| SCHEMBL7027929 | 0.86 | MTNR1A (0.65) | MTNR1AMTNR1BNPC1RAB9ADRD4 | |
| SCHEMBL7027930 | 0.86 | MTNR1A (0.65) | MTNR1AMTNR1BNPC1RAB9ADRD4 | |
| SCHEMBL7024650 | 0.84 | MTNR1A (0.50) | MTNR1AMTNR1BDRD4DRD2CYP1A2 | |
| SCHEMBL7024651 | 0.84 | MTNR1A (0.50) | MTNR1AMTNR1BDRD4DRD2CYP1A2 | |
| SCHEMBL7030412 | 0.84 | MTNR1A (0.54) | MTNR1AMTNR1BDRD4DRD2KCNH2 | |
| SCHEMBL7030407 | 0.84 | MTNR1A (0.54) | MTNR1AMTNR1BDRD4DRD2KCNH2 | |
| SCHEMBL7029145 | 0.83 | MTNR1A (0.49) | MTNR1AMTNR1BALDH1A1HPGDDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |