Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 7/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HCN1 | O60741 | 1/20 | 0.48 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024651 | 1.00 | MTNR1A (0.50) | MTNR1AMTNR1BDRD2DRD4HTR7 | |
| SCHEMBL7483377 | 0.92 | KCNH2 (0.53) | MTNR1AMTNR1BDRD2DRD4HTR7 | |
| SCHEMBL7029144 | 0.86 | MTNR1A (0.49) | MTNR1AMTNR1BDRD2DRD4HTR1A | |
| SCHEMBL7029145 | 0.86 | MTNR1A (0.49) | MTNR1AMTNR1BDRD2DRD4HTR1A | |
| SCHEMBL7024074 | 0.84 | MTNR1A (0.47) | MTNR1AMTNR1BDRD2DRD4CYP1A2 | |
| SCHEMBL7023560 | 0.84 | NPC1 (0.48) | MTNR1AMTNR1BDRD2DRD4ALOX15 | |
| SCHEMBL7023556 | 0.84 | NPC1 (0.48) | MTNR1AMTNR1BDRD2DRD4ALOX15 | |
| SCHEMBL7024065 | 0.84 | MTNR1A (0.47) | MTNR1AMTNR1BDRD2DRD4CYP1A2 | |
| SCHEMBL7027930 | 0.81 | MTNR1A (0.65) | MTNR1AMTNR1BDRD2DRD4 | |
| SCHEMBL7027929 | 0.81 | MTNR1A (0.65) | MTNR1AMTNR1BDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |
| EP-0888319-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | Astra Aktiebolag (SE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034883-A1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1997-09-25 | — | — | WO | disclosed |