Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 2/20 | 0.58 |
| ▸ | RARB | P10826 | 2/20 | 0.58 |
| ▸ | RARG | P13631 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ERN1 | O75460 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879575 | 0.90 | RARA (0.50) | RARARARBRARGALDH1A1HPGD | |
| SCHEMBL6876549 | 0.87 | RARA (0.50) | RARARARBRARGALDH1A1HPGD | |
| SCHEMBL6876543 | 0.79 | MAPK1 (0.50) | RARARARBRARGALDH1A1HPGD | |
| SCHEMBL6876542 | 0.79 | MAPK1 (0.50) | RARARARBRARGALDH1A1HPGD | |
| SCHEMBL6877068 | 0.79 | RARA (0.48) | RARARARBRARGALDH1A1HPGD | |
| SCHEMBL6870481 | 0.78 | RARA (0.46) | RARARARBRARGALDH1A1HPGD | |
| SCHEMBL7024749 | 0.78 | RARB (0.62) | RARARARBRARGALDH1A1RAB9A | |
| SCHEMBL4601799 | 0.78 | ERN1 (0.65) | ALDH1A1HPGDERN1POLBRAB9A | |
| SCHEMBL6874825 | 0.77 | RARA (0.45) | RARARARBRARGALDH1A1ERN1 | |
| SCHEMBL10352726 | 0.76 | RARA (0.61) | RARARARBRARGALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832081-B1 | BICYCLIC-AROMATIC COMPOUNDS | GALDERMA RECH DERMATOLOGIQUE (FR) | 2003-01-29 | — | — | EP | disclosed |
| EP-0832081-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1998-04-01 | — | — | EP | disclosed |
| WO-1997033881-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1997-09-18 | — | — | WO | disclosed |