Diphenylsulfane

Diphenylsulfane

SCHEMBL7024955

O=C(O)O.O=C(O)O.c1ccc(Sc2ccccc2)cc1

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of Diphenylsulfane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.62
ALDH1A1 P00352 3/20 0.62
SIRT1 Q96EB6 1/20 0.52
FFAR1 O14842 1/20 0.50
MAOA P21397 2/20 0.48
MAOB P27338 2/20 0.48
MAPT P10636 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
MGLL Q99685 1/20 0.47
HSD17B10 Q99714 1/20 0.47
CXCL12 P48061 1/20 0.47
LMNA P02545 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
BCL2 P10415 1/20 0.45
MCL1 Q07820 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
NCOA1 Q15788 1/20 0.44
NCOA3 Q9Y6Q9 1/20 0.44
NR1H2 P55055 1/20 0.43
DAO P14920 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diphenylsulfane SCHEMBL19056221 1.00 HPGD (0.62) HPGDALDH1A1SIRT1FFAR1MAOA
Diphenylsulfane SCHEMBL6843735 1.00 HPGD (0.62) HPGDALDH1A1SIRT1FFAR1MAOA
Diphenylsulfane SCHEMBL29264767 0.91 HPGD (0.60) HPGDALDH1A1SIRT1FFAR1MAOA
Diphenylsulfane SCHEMBL28278324 0.88 SIRT1 (0.59) HPGDALDH1A1SIRT1FFAR1MAOA
Diphenylsulfane SCHEMBL27619579 0.88 SIRT1 (0.59) HPGDALDH1A1SIRT1FFAR1MAOA
Diphenylsulfane SCHEMBL27611905 0.87 HPGD (0.60) HPGDALDH1A1SIRT1MAOAMAOB
Diphenylsulfane SCHEMBL28332331 0.87 HPGD (0.60) HPGDALDH1A1SIRT1MAOAMAOB
Diphenylsulfane SCHEMBL452 0.87 HPGD (0.60) HPGDALDH1A1SIRT1MAOAMAOB
Diphenylsulfane SCHEMBL27714827 0.87 HPGD (0.60) HPGDALDH1A1SIRT1MAOAMAOB
Diphenylsulfane SCHEMBL7109540 0.87 HPGD (0.60) HPGDALDH1A1SIRT1MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0856025-B1 CHOLESTERIC PHASE-FORMING POLYMERS AND THEIR USE CELANESE VENTURES GMBH (DE) 2003-01-15 EP claimed
EP-0037403-B1 HEAT ACTIVATABLE ADHESIVE WITH IMPROVED TEMPERATURE RESISTANCE MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1984-10-17 EP claimed
EP-0856025-B1 CHOLESTERIC PHASE-FORMING POLYMERS AND THEIR USE CELANESE VENTURES GMBH (DE) 2003-01-15 EP disclosed
EP-0856025-A1 CHOLESTERIC PHASE-FORMING POLYMERS, PROCESS FOR THEIR PREPARATION AND THEIR USE Hoechst Research & Technology Deutschland GmbH & Co. KG (DE) 1998-08-05 EP disclosed
WO-1997014739-A1 CHOLESTERIC PHASE-FORMING POLYMERS, PROCESS FOR THEIR PREPARATION AND THEIR USE HOECHST RESEARCH & TECHNOLOGY (DE) 1997-04-24 WO disclosed