SCHEMBL7024971

SCHEMBL7024971

C=CC(CC(=O)O)c1ccc(OC)cc1

nearest known ligand 0.80

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 8/20 0.80
KMT2A Q03164 2/20 0.50
ATM Q13315 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.48
LDHA P00338 1/20 0.44
NPC1 O15118 1/20 0.43
MAPT P10636 1/20 0.43
RAB9A P51151 1/20 0.43
PAX8 Q06710 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
HTT P42858 1/20 0.43
HPGD P15428 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27349633 0.84 FFAR1 (0.60) FFAR1KMT2AATML3MBTL1LDHA
SCHEMBL27838831 0.84 FFAR1 (0.60) FFAR1KMT2ANPSR1
SCHEMBL28769307 0.84 L3MBTL1 (0.68) FFAR1KMT2AL3MBTL1NPC1MAPT
SCHEMBL21199787 0.82 FFAR1 (0.57) FFAR1KMT2AL3MBTL1NPC1MAPT
SCHEMBL15426947 0.81 FFAR1 (0.56) FFAR1KMT2AL3MBTL1MAPT
SCHEMBL28525548 0.81 FFAR1 (0.56) FFAR1KMT2AATML3MBTL1LDHA
SCHEMBL27704468 0.81 L3MBTL1 (0.59) FFAR1KMT2AL3MBTL1NPC1MAPT
SCHEMBL27704467 0.80 FFAR1 (0.55) FFAR1KMT2AL3MBTL1NPC1MAPT
SCHEMBL3871935 0.80 FFAR1 (0.57) FFAR1KMT2AMAPTHPGD
SCHEMBL3874121 0.80 FFAR1 (0.57) FFAR1KMT2AMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934271-B1 SUBSTITUTED ARYLALKYLAMINES AS NEUROKININ ANTAGONISTS SCHERING CORP (US) 2003-09-03 EP disclosed
EP-0934271-A1 SUBSTITUTED ARYLALKYLAMINES AS NEUROKININ ANTAGONISTS SCHERING CORPORATION (US) 1999-08-11 EP disclosed
US-5789422-A PIPERIDINYL COMPOUNDS, TREATMENT OF ASTHMA, COUGH, MIGRAINE, CROHN*S DISEASE, ANTIINFLAMMATORY AGENTS SCHERING CORPORATION (US) 1998-08-04 US disclosed
WO-1998018761-A1 SUBSTITUTED ARYLALKYLAMINES AS NEUROKININ ANTAGONISTS SCHERING CORPORATION (US) 1998-05-07 WO disclosed