SCHEMBL7025147

SCHEMBL7025147

Oc1c(Cl)ccc(-c2ccccc2Cl)c1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.43
PIK3CA P42336 1/20 0.42
ALDH1A1 P00352 2/20 0.41
DPP4 P27487 1/20 0.41
LDHA P00338 1/20 0.39
TSHR P16473 2/20 0.38
IDO1 P14902 1/20 0.38
NPC1 O15118 1/20 0.38
TP53 P04637 1/20 0.38
HPGD P15428 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
LMNA P02545 1/20 0.38
PTPRC P08575 1/20 0.37
KDM4E B2RXH2 1/20 0.37
GLA P06280 1/20 0.37
PDK2 Q15119 1/20 0.37
POLB P06746 1/20 0.36
KMT2A Q03164 1/20 0.36
PLA2G7 Q13093 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5845033 0.82 NPC1 (0.47) CYP2A6PIK3CAALDH1A1DPP4TSHR
SCHEMBL2935720 0.79 AHR (0.48) CYP2A6ALDH1A1DPP4TSHRIDO1
SCHEMBL932318 0.79 IDO1 (0.50) CYP2A6PIK3CAALDH1A1DPP4TSHR
SCHEMBL1513823 0.78 CYP2A6 (0.48) CYP2A6ALDH1A1DPP4LDHAHPGD
SCHEMBL23909388 0.78 CYP3A4 (0.50) CYP2A6PIK3CAALDH1A1DPP4TSHR
SCHEMBL30335991 0.77 CYP2A6 (0.50) CYP2A6PIK3CAALDH1A1DPP4TSHR
SCHEMBL1513821 0.76 TSHR (0.62) CYP2A6PIK3CAALDH1A1DPP4TSHR
SCHEMBL29802156 0.75 CYP2A6 (0.67) CYP2A6ALDH1A1DPP4LDHATSHR
SCHEMBL29883244 0.75 CYP2A6 (0.67) CYP2A6ALDH1A1DPP4LDHATSHR
SCHEMBL671133 0.75 CYP2A6 (0.67) CYP2A6ALDH1A1DPP4LDHATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002058695-A9 (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS MERCK & CO INC (US) 2003-09-12 WO disclosed