Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7021064 | 0.86 | PRMT5 (0.46) | PRMT5TPSAB1OPRD1TSHRMEN1 | |
| SCHEMBL7022729 | 0.83 | PRMT5 (0.42) | PRMT5ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL7023114 | 0.83 | PRMT5 (0.42) | PRMT5ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL7023932 | 0.83 | PRMT5 (0.42) | PRMT5ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL7016094 | 0.78 | F2 (0.39) | PRMT5TPSAB1ALDH1A1PDE7B | |
| SCHEMBL7023796 | 0.77 | TPSAB1 (0.41) | TPSAB1ALDH1A1TSHR | |
| SCHEMBL15056838 | 0.75 | PRMT5 (0.43) | PRMT5ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL15056219 | 0.75 | PRMT5 (0.43) | PRMT5ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL15056300 | 0.75 | PRMT5 (0.43) | PRMT5ALDH1A1APPHTR1AADRA2A | |
| SCHEMBL7027708 | 0.75 | TPSAB1 (0.43) | TPSAB1ALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997474-B1 | Antithrombotic agents | PFIZER (US) | 2003-10-29 | — | — | EP | disclosed |
| US-6417203-B1 | HETEROCYCLIC AMIDES | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |
| US-6180627-B1 | INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2001-01-30 | — | — | US | disclosed |