SCHEMBL7025880

SCHEMBL7025880

NNC(=O)OCC(Cl)(Cl)Cl

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7021588 0.98 ALDH1A1 (0.39) ALDH1A1POLB
SCHEMBL25256002 0.80 ALDH1A1 (0.42) ALDH1A1POLB
SCHEMBL3361549 0.80 ALDH1A1 (0.42) ALDH1A1POLB
SCHEMBL30678963 0.78 ALDH1A1 (0.41) ALDH1A1POLB
SCHEMBL9518575 0.77 ALDH1A1 (0.38) ALDH1A1POLB
SCHEMBL10966308 0.76 ALDH1A1 (0.40) ALDH1A1POLB
SCHEMBL968360 0.76 CHRNB2 (0.43) ALDH1A1POLB
SCHEMBL22012853 0.76 ALDH1A1 (0.40) ALDH1A1POLB
SCHEMBL15500943 0.76 KMT2A (0.42) ALDH1A1
SCHEMBL11173967 0.76 HTT (0.48) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230128639-A1 PROCESS FOR PREPARING SOLUBLE GUANYLATE CYCLASE STIMULATORS TISENTO THERAPEUTICS INC. 2023-04-27 US claimed
CN-111836811-B Method for preparing soluble guanylate cyclase stimulators 帝善多制药公司 2024-11-22 CN disclosed
US-12054489-B2 Substituted amidrazones as intermediates in the process for preparing soluble guanylate cyclase stimulators TISENTO THERAPEUTICS INC. (US) 2024-08-06 US disclosed
US-20230128639-A1 PROCESS FOR PREPARING SOLUBLE GUANYLATE CYCLASE STIMULATORS TISENTO THERAPEUTICS INC. 2023-04-27 US disclosed
US-11466014-B2 Process for preparing soluble guanylate cyclase stimulators CYCLERION THERAPEUTICS, INC. (US) 2022-10-11 US disclosed
EP-0842180-B1 PENAM SULFONES AS BETA-LACTAMASE INHIBITORS NAEJA PHARMACEUTICAL INC (CA) 2003-01-22 EP disclosed
EP-0842180-A1 NOVEL PENAM SULFONES AS BETA-LACTAMASE INHIBITORS SYNPHAR LABORATORIES INC. (CA) 1998-05-20 EP disclosed
WO-1997006172-A1 NOVEL PENAM SULFONES AS BETA-LACTAMASE INHIBITORS SYNPHAR LABORATORIES, INC. (US) 1997-02-20 WO disclosed
US-4656250-A NORLEUCINE, TYROSINE, PHENYLALANINE TREATING HYPOPARATHYROIDISM TOYO JOZO KABUSHIKI KAISHA (JP) 1987-04-07 US disclosed
US-4394387-A INSECTICIDES, MITICIDES THE BOOTS COMPANY PLC (GB) 1983-07-19 US disclosed
EP-0026040-A1 Substituted benzophenone hydrazones, pesticidal compositions containing them and method of combating pests FBC LIMITED (GB) 1981-04-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230128639-A1 PROCESS FOR PREPARING SOLUBLE GUANYLATE CYCLASE STIMULATORS GUCY1A2, GUCY1B2, GUCY1A1 ALDH1A1 3061/4885POLB 4293/4885
US-11466014-B2 Process for preparing soluble guanylate cyclase stimulators GUCY1A2, GUCY1B2, GUCY1A1 ALDH1A1 1579/4885POLB 4709/4885
US-12054489-B2 Substituted amidrazones as intermediates in the process for preparing soluble guanylate cyclase stimulators GUCY1A2, GUCY1B2, PDE3A ALDH1A1 2523/4885POLB 4443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.