Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 2/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7030875 | 0.83 | MAOB (0.41) | MEN1KMT2APKMTSHRALDH1A1 | |
| SCHEMBL988905 | 0.80 | MEN1 (0.39) | MEN1KMT2APKMTSHRITGB2 | |
| SCHEMBL10088634 | 0.78 | MAOB (0.56) | CYP19A1ALDH1A1ESR1ESR2MAOB | |
| SCHEMBL3609169 | 0.74 | RXRA (0.43) | MEN1KMT2APKMALDH1A1MAPT | |
| SCHEMBL7198502 | 0.74 | RXRA (0.43) | MEN1KMT2APKMALDH1A1MAPT | |
| SCHEMBL3609173 | 0.74 | RXRA (0.43) | MEN1KMT2APKMALDH1A1MAPT | |
| SCHEMBL27548371 | 0.72 | ITGB2 (0.48) | MEN1KMT2APKMTSHRITGB2 | |
| SCHEMBL990643 | 0.70 | MEN1 (0.42) | MEN1KMT2APKMTSHRITGB2 | |
| Chromanone SCHEMBL28794 | 0.69 | MAOB (0.56) | MEN1KMT2APKMTSHRITGB2 | |
| Chromanone SCHEMBL29384996 | 0.69 | MAOB (0.56) | MEN1KMT2APKMTSHRITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596758-B1 | Treatment of dislipidaemias, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to processes allowing the preparation of these compounds. | MERCK PATENT GMBH (DE) | 2003-07-22 | — | — | US | disclosed |
| EP-1140893-B1 | BENZOPYRANS AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-05 | — | — | EP | disclosed |