SCHEMBL7027010

SCHEMBL7027010

[O-][S+](CCC=C(F)F)c1cnc2ccccc2n1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 1/20 0.36
KDM4E B2RXH2 4/20 0.33
ALDH1A1 P00352 3/20 0.33
HPGD P15428 2/20 0.33
GAA P10253 2/20 0.33
POLB P06746 2/20 0.33
ALOX15 P16050 1/20 0.33
HSD17B10 Q99714 1/20 0.33
KMT2A Q03164 4/20 0.33
MEN1 O00255 3/20 0.33
HTT P42858 2/20 0.33
MAPT P10636 2/20 0.32
BCHE P06276 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.31
NPSR1 Q6W5P4 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
HSP90AA1 P07900 1/20 0.31
HSP90AB1 P08238 1/20 0.31
NPC1 O15118 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9186126 0.72 UBE2T (0.36) KDM4EALDH1A1HPGDGAAPOLB
SCHEMBL7019639 0.71 CDK2 (0.30)
SCHEMBL9181563 0.71 NPC1 (0.37) KDM4EALDH1A1HPGDGAAHSD17B10
SCHEMBL8467073 0.69 KDM4E (0.52) PDE10AKDM4EALDH1A1HPGDGAA
SCHEMBL7104281 0.69 NPC1 (0.33) HPGDSMN1; SMN2NPC1RAB9A
SCHEMBL8752082 0.68 AURKA (0.39) KDM4EKMT2AMEN1MAPTHSP90AA1
SCHEMBL6474241 0.67 PDE10A (0.42) PDE10AKDM4EALDH1A1HPGDHSD17B10
SCHEMBL7028313 0.67 NOTUM (0.41) KDM4EALDH1A1HPGDGAAALOX15
SCHEMBL7027404 0.67 HTT (0.54) PDE10AKDM4EALDH1A1HPGDGAA
SCHEMBL7020373 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749433-B1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY SYNGENTA LTD (GB) 2003-05-07 EP disclosed
US-5952359-A NEMATICIDES, INSECTICIDES AND MITICIDES; 1,1-DIFLUORO-3-(THIAZOLYL OR ISOTHIAZOYL-THIO (OR SULFINYL OR SULFONYL)-PROP-1-ENE DERIVATIVES ZENECA LIMITED (GB) 1999-09-14 US disclosed
US-5912243-A NOVEL COMPOUNDS FOR CONTROLLING NEMATODES, INSECT OR ACARID PESTS ZENECA LIMITED (GB) 1999-06-15 US disclosed
US-5705516-A NEMATOCIDES, INSECTICIDES, ACARICIDES ZENECA LIMITED (GB) 1998-01-06 US disclosed
EP-0749433-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1996-12-27 EP disclosed
WO-1995024403-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1995-09-14 WO disclosed