Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29032682 | 0.73 | NPC1 (0.40) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL28111267 | 0.73 | MAPT (0.40) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL28023596 | 0.72 | MAPT (0.43) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL7021183 | 0.72 | NPC1 (0.41) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL7027010 | 0.71 | PDE10A (0.36) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL9186126 | 0.71 | UBE2T (0.36) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL7028313 | 0.71 | NOTUM (0.41) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL7021754 | 0.71 | NPC1 (0.47) | NPC1RAB9AMAPTTP53SMN1; SMN2 | |
| SCHEMBL7624296 | 0.69 | DDAH1 (0.60) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL14860942 | 0.68 | MAPT (0.46) | NPC1RAB9AMAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5451594-A | NEMATOCIDES, INSECTICIDES, MITICIDES AND FUNGICIDES | ZENECA LIMITED (GB) | 1995-09-19 | — | — | US | disclosed |
| EP-0660830-A1 | BENZOXAZOLE AND BEZOTHIAZOLE DERIVATIVES | ZENECA LIMITED (GB) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006782-A1 | BENZOXAZOLE AND BEZOTHIAZOLE DERIVATIVES | ZENECA LIMITED (GB) | 1994-03-31 | — | — | WO | disclosed |