Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 11/20 | 0.74 |
| ▸ | ACE | P12821 | 11/20 | 0.74 |
| ▸ | CPA1 | P15085 | 8/20 | 0.74 |
| ▸ | ACE2 | Q9BYF1 | 8/20 | 0.74 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP7 | P09237 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | MMP12 | P39900 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027395 | 1.00 | MME (0.74) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL7027401 | 1.00 | MME (0.74) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL6412463 | 0.90 | MMP1 (0.64) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL7365144 | 0.90 | ACE (0.73) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL8005905 | 0.88 | MME (0.87) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL15649671 | 0.87 | MME (0.67) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL15692372 | 0.87 | MME (0.67) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL8387156 | 0.86 | MME (0.74) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL7423453 | 0.86 | MME (0.70) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL7031374 | 0.86 | ACE (0.73) | MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140984-B1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6352976-B1 | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASE FOR EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2002-03-05 | — | — | US | disclosed |