Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP7 | P09237 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 4/20 | 0.51 |
| ▸ | CPA1 | P15085 | 2/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028765 | 1.00 | MME (0.54) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL7026577 | 0.85 | LTA4H (0.53) | MMEHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL7026556 | 0.85 | LTA4H (0.53) | MMEHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL7032498 | 0.84 | GNPAT (0.52) | MMEACECPA1ACE2HDAC3 | |
| SCHEMBL7032476 | 0.84 | GNPAT (0.52) | MMEACECPA1ACE2HDAC3 | |
| SCHEMBL7032093 | 0.83 | MME (0.71) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL7032097 | 0.83 | MME (0.71) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL7030781 | 0.83 | MME (0.57) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL30777486 | 0.82 | MME (0.65) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL15692334 | 0.82 | MME (0.65) | MMEMMP2MMP7MMP9MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140984-B1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6352976-B1 | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASE FOR EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2002-03-05 | — | — | US | disclosed |
| EP-1140984-A1 | SELECTIVE INHIBITORS OF MMP-12 | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040600-A1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |