Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763149 | 0.98 | KDM4E (0.38) | KDM4EMEN1KMT2AL3MBTL1GLA | |
| SCHEMBL3800226 | 0.76 | NPSR1 (0.38) | NPSR1MAPTSRD5A1 | |
| SCHEMBL15434645 | 0.75 | NPSR1 (0.48) | KDM4EMEN1KMT2AL3MBTL1GLA | |
| SCHEMBL5807749 | 0.72 | NPSR1 (0.47) | KDM4EMEN1KMT2AL3MBTL1GLA | |
| SCHEMBL3277032 | 0.71 | GAA (0.39) | KDM4EMEN1KMT2AL3MBTL1GLA | |
| SCHEMBL2059464 | 0.68 | CDC7 (0.35) | KDM4EMEN1KMT2AL3MBTL1NPSR1 | |
| SCHEMBL5810793 | 0.67 | KDM4E (0.39) | KDM4EMEN1KMT2AGLANPSR1 | |
| SCHEMBL18120869 | 0.67 | GAA (0.33) | NPSR1MCL1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL9024724 | 0.67 | GAA (0.46) | KDM4EMEN1KMT2AL3MBTL1GLA | |
| SCHEMBL1034284 | 0.67 | NPSR1 (0.35) | NPSR1MAPTSRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383747-A1 | FUSED PYRIMIDINES AS ANTAGONISTS OF THE CORTICOTROPIN RELEASING FACTOR (CRF) | GLAXO GROUP LIMITED (GB) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002088095-A1 | FUSED PYRIMIDINES AS ANTAGONISTS OF THE CORTICOTROPIN RELEASING FACTOR (CRF) | GLAXO GROUP LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |