SCHEMBL70296

SCHEMBL70296

O=[N+]([O-])c1cccnc1SS

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
MAPT P10636 5/20 0.56
ALDH1A1 P00352 4/20 0.54
GAA P10253 2/20 0.54
PKM P14618 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
PDE10A Q9Y233 1/20 0.51
POLB P06746 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
MAPK1 P28482 1/20 0.48
CYP1A2 P05177 2/20 0.46
CYP2C9 P11712 2/20 0.46
NCOA1 Q15788 1/20 0.46
NCOA3 Q9Y6Q9 1/20 0.46
CYP2C19 P33261 1/20 0.46
HTT P42858 1/20 0.46
RAB9A P51151 2/20 0.45
LMNA P02545 2/20 0.43
PAX8 Q06710 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28117652 0.89 GAA (0.56) MEN1KMT2AMAPTALDH1A1GAA
SCHEMBL29627490 0.85 MEN1 (0.61) MEN1KMT2AMAPTALDH1A1GAA
SCHEMBL6849222 0.85 MEN1 (0.71) MEN1KMT2AMAPTALDH1A1GAA
SCHEMBL70297 0.85 MEN1 (0.61) MEN1KMT2AMAPTALDH1A1GAA
SCHEMBL1763611 0.81 MEN1 (0.58) MEN1KMT2AMAPTALDH1A1GAA
SCHEMBL6967207 0.81 MEN1 (0.58) MEN1KMT2AMAPTALDH1A1GAA
SCHEMBL112949 0.81 MEN1 (0.58) MEN1KMT2AMAPTALDH1A1GAA
SCHEMBL927388 0.81 MEN1 (0.62) MEN1KMT2AMAPTALDH1A1GAA
SCHEMBL795882 0.81 MEN1 (0.62) MEN1KMT2AMAPTALDH1A1GAA
SCHEMBL4988971 0.81 SMN1; SMN2 (0.61) MEN1KMT2AMAPTALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4836 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12478695-B2 Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof HANGZHOU DAC BIOTECH CO., LTD. (CN) 2025-11-25 US claimed
US-12303571-B2 Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof HANGZHOU DAC BIOTECH CO., LTD. (CN) 2025-05-20 US claimed
US-11779663-B2 Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-10-10 US claimed
EP-3122757-B1 CHARGED LINKERS AND THEIR USES FOR CONJUGATION HANGZHOU DAC BIOTECH CO LTD (CN) 2023-09-06 EP claimed
US-20230001001-A1 CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-01-05 US claimed
US-20210393790-A1 CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE HANGZHOU DAC BIOTECH CO., LTD. (CN) 2021-12-23 US claimed
EP-3912982-A1 NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF Hangzhou Dac Biotech Co., Ltd (CN) 2021-11-24 EP claimed
US-20210353777-A1 SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF HANGZHOU DAC BIOTECH CO., LTD. (CN) 2021-11-18 US claimed
US-20210346523-A1 SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF HANGZHOU DAC BIOTECH CO., LTD. (CN) 2021-11-11 US claimed
EP-3271329-B1 NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF HANGZHOU DAC BIOTECH CO LTD (CN) 2021-08-18 EP claimed
US-20150314017-A1 DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE SUZHOU M-CONJ BIOTECH CO., LTD (CN) 2015-11-05 US claimed
US-20150166482-A1 METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS IMMUNOGEN, INC. 2015-06-18 US claimed
US-8754039-B2 Targeted antimicrobial moieties C3 JIAN, INC. (US) 2014-06-17 US claimed
US-8598362-B2 Methods for the preparation of charged crosslinkers IMMUNOGEN, INC. (US) 2013-12-03 US claimed
EP-2648510-A1 METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS ImmunoGen, Inc. (US) 2013-10-16 EP claimed
US-8236319-B2 Cross-linkers and their uses IMMUNOGEN, INC. (US) 2012-08-07 US claimed
US-20120165537-A1 METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS IMMUNOGEN, INC. (US) 2012-06-28 US claimed
WO-2012078868-A1 METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS IMMUNOGEN, INC. (US) 2012-06-14 WO claimed
US-RE35524-E Epipodophyllotoxin glucoside 4'-phosphate derivatives BRISTOL-MYERS SQUIBB COMPANY (US) 1997-06-03 US claimed
US-4904768-A Epipodophyllotoxin glucoside 4'-phosphate derivatives BRISTOL-MYERS COMPANY (US) 1990-02-27 US claimed