SCHEMBL7030241

SCHEMBL7030241

C=CCOCc1ccc(-c2ccc([C@H]3CC[C@H](CC=C)CC3)cc2)cc1F

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GBA1 P04062 2/20 0.33
LCT P09848 2/20 0.33
UGCG Q16739 2/20 0.33
GBA2 Q9HCG7 2/20 0.33
MGAM O43451 1/20 0.33
SI P14410 1/20 0.33
NAAA Q02083 1/20 0.33
ESR1 P03372 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
ESR2 Q92731 1/20 0.31
FFAR4 Q5NUL3 1/20 0.30
NR1H4 Q96RI1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7024993 0.89 ESR2 (0.33) GBA1LCTUGCGGBA2MGAM
SCHEMBL7033562 0.88 GBA1 (0.34) GBA1LCTUGCGGBA2MGAM
SCHEMBL7029773 0.88 CYP2C9 (0.39) GBA1LCTUGCGGBA2MGAM
SCHEMBL7020366 0.87 ESR2 (0.31) ESR1CYP3A4CYP2C9ESR2
SCHEMBL7032403 0.85 GBA1 (0.33) GBA1LCTUGCGGBA2MGAM
SCHEMBL8385815 0.84 FFAR4 (0.33) GBA1LCTUGCGGBA2MGAM
SCHEMBL8725021 0.82 GBA1 (0.31) GBA1LCTUGCGGBA2MGAM
SCHEMBL8725027 0.82 GBA1 (0.31) GBA1LCTUGCGGBA2MGAM
SCHEMBL8725023 0.82 GBA1 (0.31) GBA1LCTUGCGGBA2MGAM
SCHEMBL8727817 0.82 ESR2 (0.36) NAAAESR1CYP3A4CYP2C9ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0754668-B1 Fluorobenzylether derivatives ROLIC AG (CH) 2003-02-05 EP disclosed
EP-0754668-A2 Fluorobenzylether derivatives Rolic AG (CH) 1997-01-22 EP disclosed