Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 11/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037792 | 0.89 | MAPK13 (0.41) | MAPK13MAPK12MAPK11MAPK14KDM4C | |
| SCHEMBL7038999 | 0.89 | CYP11B2 (0.44) | MAPK13MAPK12MAPK11MAPK14KDM4C | |
| SCHEMBL7030642 | 0.88 | KDM4C (0.44) | MAPK13MAPK12MAPK11MAPK14KDM4C | |
| SCHEMBL7512487 | 0.88 | MAPK13 (0.40) | MAPK13MAPK12MAPK11MAPK14KDM4C | |
| SCHEMBL7033586 | 0.86 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14TYK2 | |
| SCHEMBL7040291 | 0.86 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7036626 | 0.85 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7040242 | 0.83 | MAPK13 (0.52) | MAPK13MAPK12MAPK11MAPK14LMNA | |
| SCHEMBL7033522 | 0.83 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14GRM4 | |
| SCHEMBL7034038 | 0.82 | MAPK14 (0.76) | MAPK13MAPK12MAPK11MAPK14TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | claimed |
| EP-1289958-A2 | BENZOPHENONES AS INHIBITORS OF IL-1$g(b) AND TNF-$g(a) | Leo Pharma A/S (DK) | 2003-03-12 | — | — | EP | disclosed |
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | disclosed |
| WO-2001090074-A2 | BENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | LEO PHARMA A/S (DK) | 2001-11-29 | — | — | WO | disclosed |