Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7030739 | 0.88 | MAPK13 (0.53) | KDM4CMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7038999 | 0.86 | CYP11B2 (0.44) | KDM4CMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7037792 | 0.84 | MAPK13 (0.41) | KDM4CMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7035322 | 0.83 | MAPK13 (0.38) | KDM4CMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7030706 | 0.82 | MAPK13 (0.57) | KDM4CMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7512487 | 0.76 | MAPK13 (0.40) | KDM4CMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7513571 | 0.75 | MAPK13 (0.37) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL7033586 | 0.74 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14DHODH | |
| SCHEMBL7040291 | 0.74 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14SMN1; SMN2 | |
| SCHEMBL7036626 | 0.73 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | claimed |
| EP-1289958-A2 | BENZOPHENONES AS INHIBITORS OF IL-1$g(b) AND TNF-$g(a) | Leo Pharma A/S (DK) | 2003-03-12 | — | — | EP | disclosed |
| US-6432962-B2 | Benzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2002-08-13 | — | — | US | disclosed |
| WO-2001090074-A2 | BENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | LEO PHARMA A/S (DK) | 2001-11-29 | — | — | WO | disclosed |