Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.56 |
| ▸ | DRD3 | P35462 | 11/20 | 0.56 |
| ▸ | DRD1 | P21728 | 4/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7025402 | 1.00 | DRD2 (0.56) | DRD2DRD3DRD1DRD4CYP1A2 | |
| SCHEMBL6816670 | 0.91 | DRD2 (0.48) | DRD2DRD3 | |
| SCHEMBL7030108 | 0.91 | DRD2 (0.48) | DRD2DRD3 | |
| SCHEMBL8157601 | 0.91 | DRD2 (0.48) | DRD2DRD3 | |
| SCHEMBL7239524 | 0.84 | DRD2 (0.43) | DRD2DRD3 | |
| SCHEMBL7027796 | 0.83 | DRD2 (0.51) | DRD2DRD3DRD1DRD4CYP1A2 | |
| SCHEMBL7025218 | 0.83 | DRD2 (0.51) | DRD2DRD3DRD1DRD4CYP1A2 | |
| SCHEMBL7020675 | 0.83 | DRD2 (0.52) | DRD2DRD3 | |
| SCHEMBL6819394 | 0.83 | DRD2 (0.43) | DRD2DRD3DRD1CYP1A2CYP3A4 | |
| SCHEMBL7244550 | 0.83 | DRD2 (0.46) | DRD2DRD3DRD1DRD4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |